General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter Jurkat IκB Degradation Cell Line, 2 vials. (93-1121C19)
The PathHunter Jurkat IκB Degradation Cell Line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting the NFκB pathway. This cell line enables detection of IκB levels, allowing for assessment of NFκB pathway activation-induced IκB degradation. This product uses EFC technology. The cell line included overexpresses IκB target protein fused to ProLabel. EA is contained in the detection reagent. Upon pathway-activation-induced degradation of IκB EFC signal is lost. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/pathways.
Eurofins Discoverx PathHunter U2OS TGFBR1/TGFBR2/ENG Dimerization Cell Line, 2 vials. (93-1122C3)
The PathHunter TGFBR1/TGFBR2/ENG Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. TGF-β1) induced dimerization of TGFBR1/TGFBR2/ENG receptors. This product uses EFC technology. The cell line included overexpresses TGFBR1 target protein fused to PK alongside TGFBR2 target protein fused to EA and untagged ENG. Upon ligand-induced dimerization of TGFBR1/TGFBR2/ENG, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Genscript Corporation CHO-K1/CCKB Stable Cell Line
Human Recombinant CHO-K1/CCKB Stable Cell Line stably overexpress the Cholecystokinin Receptor gene (CCKB) This stable cell line product is designed for measuring the In Vitro function of CCKB
Genscript Corporation CHO-K1/NK2 Stable Cell Line
Tachykinins are peptides sharing a common C-terminal amino acid sequence Phe-X-Gly-Leu-Met-NH sub 2 /sub This neuropeptide family is composed of substance P neurokinin A and neurokinin B which are widely distributed in mammalian central and peripheral nervous systems These three molecules serve as both neurotransmitters and neuromodulators Their actions are mediated by binding with three distinct receptors namely NK1 NK2 and NK3 In particular NK2 is expressed in gastrointestinal tract Activation of NK2 is chiefly responsible for the regulation of intestinal motor functions (both excitatory and inhibitory) secretions inflammation and visceral sensitivity Antagonists of NK2 may be useful in the treatment of irritable bowel syndrome
Eurofins Discoverx PathHunter HEK 293 IFNAR1/IFNAR2 Dimerization Cell Line, 2 vials. (93-1097C1)
The PathHunter IFNAR1/IFNAR2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IFN-beta) induced dimerization of IFNAR1/IFNAR2 receptors. This product uses EFC technology. The cell line included overexpresses IFNAR2 target protein fused to PK alongside IFNAR1 target protein fused to EA. Upon ligand-induced dimerization of IFNAR1/IFNAR2, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
Biolegend PE/Fire™ 700 anti-mouse CD192 (CCR2) [SA203G11]; Isotype: Rat IgG2b, κ; Reactivity: Mouse; Apps: FC; Size: 100 μg
PE/Fire™ 700 anti-mouse CD192 (CCR2) [SA203G11]; Isotype: Rat IgG2b, κ; Reactivity: Mouse; Apps: FC; Size: 100 μg
Biolegend PE/Fire™ 700 anti-mouse CD192 (CCR2) [SA203G11]; Isotype: Rat IgG2b, κ; Reactivity: Mouse; Apps: FC; Size: 25 μg
PE/Fire™ 700 anti-mouse CD192 (CCR2) [SA203G11]; Isotype: Rat IgG2b, κ; Reactivity: Mouse; Apps: FC; Size: 25 μg
Eurofins Discoverx PathHunter HEK 293 cyno CXCR2 β-Arrestin Cell Line, 2 vials. (93-0981C1)
The PathHunter cyno CXCR2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL8/IL8) based activation of CXCR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged cyno CXCR2 and EA-tagged β-Arrestin-2. Activation of CXCR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Cynomolgus monkey version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx cAMP Hunter CHO-K1 CHRM2 Gs Cell Line, 2 vials. (95-0078C2)
The cAMP Hunter CHRM2 Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. oxotremorine) based activation of CHRM2 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CHRM2, a naturally Gs coupled GPCR. Upon activation of CHRM2, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx cAMP Hunter CHO-K1 CNR1 Gi Cell Line, 2 vials. (95-0071C2)
The cAMP Hunter CNR1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CP 55,940) based activation of CNR1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CNR1, a naturally Gi/Go coupled GPCR. Upon activation of CNR1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS IL5RA/CSF2RB Dimerization Cell Line, 2 vials. (93-0972C3)
The PathHunter IL5RA/CSF2RB Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-5) induced dimerization of IL5RA/CSF2RB receptors. This product uses EFC technology. The cell line included overexpresses CSF2RB target protein fused to PK alongside IL5RA target protein fused to EA. Upon ligand-induced dimerization of IL5RA/CSF2RB, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
XenoTech,LLC Pooled Fischer 344 rat liver microsomes, male, 0.5 ML at 20 ME/ML (10 ME)
Pooled Fischer 344 rat liver microsomes, male, 0.5 ML at 20 ME/ML (10 ME)
XenoTech,LLC Pooled dexamethasone-treated SD rat liver microsomes, male, 0.5 ML at 20 ME/ML (10 ME)
Pooled dexamethasone-treated SD rat liver microsomes, male, 0.5 ML at 20 ME/ML (10 ME)