General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter U2OS EGFR/EGFR Dimerization Cell Line, 2 vials. (93-0989C3)
The PathHunter EGFR/EGFR Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. EGF) induced dimerization of EGFR/EGFR receptors. This product uses EFC technology. The cell line included overexpresses EGFR target protein fused to PK alongside EGFR target protein fused to EA. Upon ligand-induced dimerization of EGFR/EGFR, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter GLP2R Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0750C3)
The PathHunter GLP2R Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of GLP2R via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged GLP2R. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting GLP2R-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC T98G; Glioblastoma Multiforme; Human (Homo sapiens)
T98G [T98-G] is a fibroblast-like cell that was isolated from the brain of a glioblastoma multiforme White, 61-year-old, male patient. This cell line was deposited by GH Stein and can be used in neuroscience research.
Miltenyi Biotec, Inc. LRSC CD19 MicroBead Kit, human
Positive isolation of CD19+ cells directly from LRSC
ATCC Pseudomonas putida; KT2440
Pseudomonas putida strain KT2440 is a whole-genome sequenced strain that can be used as a transformation host. This strain is genotype rmo- mod+.
Eurofins Discoverx PathHunter U2OS CSF3R-JAK1 Functional Assay, 2 vials. (93-0809C3)
The PathHunter CSF3R-JAK1 Functional assay cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting CTKs. This cell line enables assessment of CSF3R activation via detection of JAK1 mediated phosphorylation-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged CSF3R cytokine receptor, an untagged CTK JAK1 and EA-tagged SH2 domain protein. Upon activation of the cytokine receptor, CTK-based receptor phosphorylation leads to SH2-EA recruitment and production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter CHO-K1 GPR152 β-Arrestin Orphan GPCR Cell Line, 2 vials. (93-0384C2A)
The PathHunter GPR152 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of GPR152 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR152 and EA-tagged β-Arrestin-2. Activation of GPR152 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. This is an orphan receptor without a known ligand. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Genscript Corporation CHO-K1/CT/G15 Stable Cell Lin
Recombinant CHO-K1 cells stably overexpress human calcitonin receptor (CT) on the surface and contain high levels of G protein G q and G s to couple with the receptor in downstream signaling pathways
Revvity Health Sciences Inc AequoZen Human Calcitonin CGRP1 Cell Line, CHO-K1 Frozen Cells
AequoZen Human Calcitonin CGRP1 Cell Line, CHO-K1 Frozen Cells
ATCC Staphylococcus saprophyticus; 6 x 0.3mL
ATCC BAA-750-MINI-PACK™ consists of 6 ready-to-use vials of ATCC BAA-750™ frozen in 200 μL of glycerol stock, eliminating the need to rehydrate and culture the strain prior to use. Each vial is provided with a 2-D barcode for easy storage and tracking, as well as peel-off labels for fast and reliable recordkeeping.
ATCC Alistipes shahii; WAL 8301
Alistipes shahii is a whole-genome sequenced bacterial type strain. This strain is propagated anaerobically.
ATCC HCM-BROD-0011-C71; Cancer Model Primary; Glioblastoma Brain; Human (Homo sapiens)
A patient-derived next-generation cancer model generated by the Human Cancer Models Initiative (HCMI). HCM-BROD-0011-C71 (ATCC No. PDM-18) was isolated from primary glioblastoma of brain tissue. This tumor-derived model can be used in basic research and pharmacological screening applications. Data for the parental tumor and the tumor-derived organoid models are available at the GDC. Additional molecular characterizations may be available at the GDC. Additional controlled data may be available via dbGaP.
ATCC Streptococcus pyogenes group a
Streptococcus pyogenes strain NCTC 8360 is typed as Lancefield's group A. This strain has applications as a bacteriophage host and in emerging infectious disease research.
ATCC Klebsiella pneumoniae; Strain 1100975
Klebsiella pneumoniae subsp. pneumoniae strain 1100975 is a whole-genome sequenced bacterium that was isolated from a respiratory sample. This strain is resistant to ertapenem, doripenem, imipenem, and meropenem and was confirmed by PCR to contain the blaNDM gene. The strain can be used in antimicrobial resistance research, drug development, infectious disease research, and respiratory disease research.